A negative test result does not confirm the absence of cancer. Patients with a positive test result should be referred for colonoscopy. ![]() A positive test result does not confirm the presence of cancer. The Cologuard test result should be interpreted with caution. Cologuard performance in repeat testing has not been evaluated. Cologuard performance in adults ages 45-49 is estimated based on a large clinical study of patients 50 and older. ![]() Cologuard is not a replacement for colonoscopy in high risk patients. Do not use if you have had adenomas, have inflammatory bowel disease and certain hereditary syndromes, or a personal or family history of colorectal cancer. Cologuard is intended to screen adults 45 years of age and older who are at average risk for colorectal cancer by detecting certain DNA markers and blood in the stool.
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